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KMID : 0367419690120080023
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Journal of Korean Pediatric Society
1969 Volume.12 No. 8 p.23 ~ p.31
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Investigation on Extrapulmonary Oxygenation of Hydrogen Peroxide and Oxygen
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Abstract
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Investigation on extrapulmonary oxygenation was performed in dogs and rabbits by intestinal perfusion .of hydrogen peroxide and oxygen. For the single administration, 0.4% hydrogen peroxide can be given with a dose of 10 ml. per kilogram of body weight safely by enema preferably without doing any enema before the procedure, which would give maximum oxygenation in both portal vein and inferior vena cava without forming gas emboli. Higher than this concentration would cause gas bubbles in portal vein. In the serial administration, 0.2% hydrogen peroxide can be given by enema alternately exchanging the intestinal contents with 10 to 15 minutes intervals, preferably with human whole blood (1.0 ml. per kilogram of body weight) to have a prolonged higher oxygenation in portal vein, inferior vena cava and :femoral artery, which would not cause gas emboli in portal vein. The above concentrations of hydrogen peroxide could be utilized in pediatric practice if proved these would not form methemoglobin in the blood.
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